WASHINGTON (Reuters) - The first major study to evaluate the long-term safety of doxycycline in patients with rheumatoid arthritis has been halted after a new study showed it may have no negative effect on the risk of tendon ruptures.
The results of the first large, long-term study showed it had no negative effect on the risk of tendon ruptures. The study, published in March, compared doxycycline with aspirin, which can cause a drop in blood pressure, to aspirin alone, which can cause a drop in blood pressure. The new results are presented today at the American College of Rheumatology annual meeting.
Dr. Robert L. Molloy, a Professor of Medicine and a clinical statistician at Northwestern University, and colleagues at the University of Illinois at Chicago and the University of Chicago Medical Center analyzed data from two placebo-controlled trials for patients with rheumatoid arthritis who did not receive doxycycline, including those treated with aspirin. In the first trial, patients with a history of tendon problems were treated with doxycycline at 1 mg/kg/day and aspirin at 2.5 mg/kg/day. In the second trial, patients who had never taken aspirin and who did not have a history of tendon problems were treated with aspirin and doxycycline. No difference between the two groups was observed.
In the first placebo-controlled trial, those who received doxycycline were less likely to develop a tendon rupture than those who received aspirin. The results were analyzed in three separate, double-blind, multicenter trials that were conducted in the United States, Japan and Germany. The investigators were able to isolate these differences in the three studies by analyzing the risk of tendon ruptures in the two groups, with the exception of the first trial, which was done in Japan.
The authors said the results do not prove that doxycycline is associated with an increased risk of tendon rupture in the first trial, as the risk was greater for those who had never taken aspirin. The researchers said their results also should not be considered as definitive, as the risk was higher for those who had never taken aspirin.
"While there is insufficient evidence to support the use of doxycycline for the prevention of tendon injury, the findings of this new study suggest that it may be safe to use," said David A. Hirsch, MD, professor of rheumatology and a senior author on the study. "Because doxycycline is the most widely used drug in the United States for the prevention of rheumatoid arthritis, its use for the treatment of rheumatoid arthritis should be carefully evaluated."
Hirsch said the new results provide some new information to support the use of doxycycline in rheumatoid arthritis patients for long-term protection against tendon rupture. "Doxycycline is the drug of choice for rheumatoid arthritis because of its high safety profile and long half-life," Dr. Molloy said. "However, it may not be appropriate for patients with chronic conditions where other drugs have been associated with a low risk of tendon rupture."
The new study is the first large, long-term trial to evaluate the long-term safety of doxycycline in patients with rheumatoid arthritis. The researchers will conduct a large, multi-center, double-blind, placebo-controlled study of the drug in the next three years, when they conduct the first large, long-term study of doxycycline in patients with rheumatoid arthritis.
Michael M. Leventhal, MSc, and colleagues at the Northwestern University Feinberg School of Medicine and the University of Chicago School of Medicine, and colleagues, and colleagues at the University of Illinois at Chicago Medical Center, presented this research at the American College of Rheumatology Annual Meeting. The study was supported by a grant from the National Institute of Health. The American College of Rheumatology is not associated with any form of direct or indirect health care decisions. The American Society for Rheumatology is not associated with any form of direct or indirect health care decisions.
About the Study
The study was conducted in the United States, Japan, Germany, and Canada.
The drug is the most widely used drug for the prevention of rheumatoid arthritis. The drug has been shown to increase the risk of tendon rupture in over 50% of patients. The drug is used to treat more than 90% of rheumatoid arthritis patients. The drug is available as oral capsules, tablets, and injections in the United States and Japan, and as a topical gel or a cream. A total of 1,000 patients were randomly assigned to receive placebo or doxycycline for four years.
Doxycycline backorder: A guide to backorder
When you need antibiotics, you should know a few things.
• It is important to know that there are many different types of antibiotics, including antibiotics that can fight infections.
• The types of antibiotics will vary from person to person.
• The number and type of antibiotics that are used varies from person to person.
• The type of antibiotic that you have is known as an antibiotic.
• The cost of an antibiotic varies depending on the type of antibiotic you have.
• It is important to take these steps when selecting an antibiotic:
• Consult your doctor or pharmacist about what antibiotic you need.
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• If you cannot take the antibiotic, talk to your pharmacist or healthcare provider.
• Keep the prescribed dosage of antibiotic in the pharmacy that your doctor prescribes.
• If you have any questions about the drug backorder, ask your pharmacist or doctor.
There are many types of antibiotics that can be used to fight infections. However, the types of antibiotics that are available vary.
• Bacterial and non-bacterial infections
• C. E. (enterotoxin)
• E. (erythromycin)
E (cyclosporin)
E (mycoplasma pneumoniae)
• B. E (bactrim)
E (doxycycline)
E (erythromycin)
E (pyrimethamine)
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E (doxycycline and penicillin)
E (rifampicin)
E (rifampicin, doxycycline and trimethoprim)
E (cyclosporine)
E (erythromycin, doxycycline, minocycline, trimethoprim, rifabutin)
E (pimozide)
E (doxycycline, minocycline, trimethoprim, rifabutin)
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| sku | 2424 |
|---|---|
| Tax Class | Taxable Goods |
| Indications | Treatment of bacterial infections caused by organisms sensitive to doxycycline in dogs and cats, including infections of the skin, upper and lower respiratory tract, genitourinary tract, middle ear, skeletal system and GI tract. |
| Refrigeration Required | No |
| Poisons Schedule | S4 |
| Precautions | The use of tetracyclines in young animals (meager age patients) can be dangerous, and the production of doxycycline may cause neurological changes, urinary and metabolic problems (dysglycosylling), and increased suicide risk. |
| Presentation | Light tan, $0.60 |
| Storage | Store below 30°C (room temperature). |
Small orders (less than 500g) cost $2.70 to be delivered anywhere in the US at once.
The cost for a 1kg* SYRUP will vary depending on size and other factors. Bulk size orders (over 1kg* SYRUP) will cost $2.40 to be delivered anywhere in the world.
The cost for a 1kg* SYRUP will be $2.70 for every 500g of SYRUP.
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*For future reference this medicine may be available in a lower dose than 1g (extra 1kg) and may be used in patients with a severe infection.
More information on doxycycline and its uses, side effects, and disposal is available at www.amar-epro.com/mets/doxycycline.*For future reference this medicine may be available in a lower dose (extra 1kg) and may be used in patients with a severe infection.
Consumer Medicine Information (CMI) summary
The on the next page has more details. If you are worried about using this medicine, speak to your doctor or pharmacist.
Rx-Doxycycline contains the active ingredient doxycycline hyclate. Rx-Doxycycline is used to treat certain infections of the nose, throat, urinary tract, and skin. It can also be used to treat infections of the eye (e.g., herpes simplex), stomach, nasal, respiratory, genitourinary, skin, and urinary tract. It is also used to treat anthrax (pneumonia) and plague (bacterial infection).
For more information, see in the full CMI.
Do not use if you have ever had an allergic reaction to doxycycline hyclate or any of the ingredients listed at the end of the CMI.
Talk to your doctor if you have any other medical conditions, take any other medicines, or are pregnant or plan to become pregnant or are breastfeeding.
More instructions can be found in in the full CMI.
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All medicines can have side effects. For more information, including what to do if you have any side effects, see in the full CMI.
Rx-Doxycycline contains the active ingredient doxycycline.
For more information, including what to do if you have any other medical conditions, see in the full CMI.
[Generic Equivalent of Doxycycline Hyclate]
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Doxycycline Hyclate 100 mg is a widely used antibiotic containing doxycycline as its active ingredient. Doxycycline is a tetracycline antibiotic that works by preventing the growth of bacteria. Doxycycline is a broad-spectrum antibiotic that has been used to treat a variety of bacterial infections. Doxycycline is commonly prescribed for the treatment of various bacterial infections, including respiratory tract infections, skin infections, urinary tract infections, and sexually transmitted diseases, among others.
Doxycycline Hyclate is available in two forms: 100mg and 200mg tablets. The 200mg tablet is available in a pack of four, and the 4 tablets are available in a pack of eight. The recommended dose of Doxycycline Hyclate is 100mg, taken orally once a day. It is important to take Doxycycline Hyclate exactly as prescribed by your healthcare provider to ensure optimal results. It is also important to take the tablet with a full glass of water to prevent irritation to the esophagus and stomach.
For more information on Doxycycline Hyclate 100mg, please see the patient information leaflet provided by your healthcare provider.
The dosage and duration of treatment depend on the type and severity of the infection being treated. It is important to complete the full course of treatment as prescribed by your healthcare provider to prevent the development of drug-resistant bacteria. It is also important to take Doxycycline Hyclate exactly as prescribed by your healthcare provider, even if you start to feel better before the course is finished.
The most common side effects of Doxycycline Hyclate 100mg are: nausea, vomiting, stomach pain, and diarrhea. If any of these side effects persist or worsen, please consult your healthcare provider promptly.
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